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KMID : 1156220060320030235
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Journal of Environmental Health Sciences
2006 Volume.32 No. 3 p.235 ~ p.239
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The Effect of Cichorium intybus Extract on Hepatotoxicity in Rats
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Park Ji-Young
Kim Eun-Kyung
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Abstract
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Cichorium intybus (Compositae) has been used for fevers, dyspepsia, headache and jaundice, as a demulcent. Also, it has relaxation effects and relief effects against coffee and teas, and is widely used as food. We investigated anti-lipid peroxidative effects and liver protective activity on CCl₄ induced lipid peroxidation and hepatotoxicity in rats. MeOH Ex. enhanced the inhibition of anti-lipid peroxidative effects in liver lipid. In chemical parameters obtained from serum analysis, MeOH Ex. revealed significant decrease on hepatotoxicity. The results were as follows; 1. The inhibitory effects of lipid peroxidation were shown in accordance with the increase of samples’ concentration level. 2. In chemical parameters obtained from serum analysis, the activities of GOT, GPT, AlP were restored to near the normal level. The contents of cholesterol and BUN showed inhibitory effects with valence. 3. The weights of liver and spleen were not able to restore to the normal level. But on a general level, they were reduced more than the control group.
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KEYWORD
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Cichorium intybus, anti-lipid peroxidation, hepatotoxicity
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